Saturday, August 31, 2019

Investigational New Drug Review Process

INVESTIGATIONAL NEW DRUG REVIEW PROCESS Investigational New Drug Review Process Prashanth Kumar Ponugoti Northeastern University INVESTIGATIONAL NEW DRUG REVIEW PROCESS Abstract Investigational New Drug (IND) review process begins from the time the sponsor files investigation new drug application and the purpose of the review is to confirm the safety and efficacy of the patient for the drug.Moreover in the process of review if the review committee notifies any deficiencies by the new drug then there will be a clinical however if there are no deficiencies the drug will be approved for new drug application and will be under continuous review to make sure , that the drug does not cause any potential harm. This entire step wise process of review is explained in the following paper INVESTIGATIONAL NEW DRUG REVIEW PROCESS The following flow chart gives an overview of the IND review process Applicant (Drug Sponsor)IND Review by CDER Statistical Pharmacology/ Toxicology Medical Chemistry Spo nsor Submits New Data Safety Review Safety acceptable for study to proceed Clinical Hold Decision Notify Sponsor Complete reviews Reviews Complete and Acceptable? Sponsor Notified of Deficiencies No Deficiencies Study Ongoing INVESTIGATIONAL NEW DRUG REVIEW PROCESS I. Applicant (Drug sponsor): An applicant or the sponsor is a person or a group who takes responsibility and initiates for the investigation of new drug.A person other than an individual that uses one or more of its own employees to conduct an investigation that it has initiated is a sponsor. The sponsor may be an individual, partnership, government agency, private agency, or any other organization and moreover the sponsor does not conduct the investigation process unless the sponsor is a sponsor-investigator. The applications are submitted to Center for Drug Evaluation and Research (CDER) Food and Drug Administration Document and Records Section 5901-B Ammendale Rd. Beltsville, Md. 20705-1266 II.Investigational New Drug Application: Sponsor thinks about new drug application when he has a successful results in preclinical studies (The studies conducted in animals to find the use of drug in human and ensure safety and efficacy) in other words it is the step taken after the successful preclinical studies to continue further studies that is clinical trial in humans. During the conduct of preclinical trial, step by step information of the process is recorded as data and stored. Thus stored information is helpful in filling an IND. The information is as follows A. Animal Pharmacology and toxicology studiesB. Manufacturing Information C. Clinical protocols and investigators information Animal Pharmacology and toxicology studies: The studies conducted in animals to ensure the use of the product is reasonably safe for initial testing in humans. Manufacturing Humans: This is the information obtained from manufacturing, storage, composition, storage and stability, for manufacturing of drug substance and produ ct. Clinical protocols and investigators information: protocols for proposed clinical studies to assess whether the initial-phase trials will expose subjects to unnecessary risks.Information on the qualifications of clinical investigators—professionals who oversee the administration of the experimental compound–to assess whether they are qualified to fulfill their clinical trial duties. The IND is not a marketing approval but The IND is the means through which the sponsor officially obtains this exemption from the FDA: however, its main intention is to detail the data that provide documentation that it is indeed reasonable to proceed with certain human trials with the drug. Types of INDs i. Investigator INDs ii. Emergency Use INDs and iii.Treatment IND After the submission of the IND to the Center for Drug Evaluation and Research (CDER) committee it checks thoroughly the medical, chemistry, toxicological, and statistical data INVESTIGATIONAL NEW DRUG REVIEW PROCESS The se terms are explained below in detail III. Medical Review: Medical also called as clinical review is conducted by medical officers or physicians to ensure the initial use of the drug in patients and are safe to use . This review is also conducted by the non medical officers based upon the data available from the re clinical studies.Medical review plays a major role in new drug review process and is an initiating step for the test of the drug in humans: however it is an important step to be conducted and based upon the results obtained from the review it has a further scope to apply for next steps that is to file new drug application. During this review process the medical reviewers or physicians evaluate the clinical trial protocol for to determine A. If the participants will be protected from unnecessary risks; and B. If the study design will provide data relevant to the safety and effectiveness of the drug.However the safety of the drug is taken by the sponsor during the phase I studies but during phase II, III, and IV Food and Drug Administration (FDA) must also ensure the safety of the medicament in humans for market approval. IV. Chemistry Review: Each review committee has an chemistry review department for reviewing the chemistry of the drug and the agenda of this chemistry department is to address issues related to drug identity, manufacturing control, and analysis. The reviewing committee ensures that the investigational new drug is adequately reproducible and stable.If the drug is neither adequately reproducible nor stable then the chances of approval for IND are less because they are not sure about the drugs action in the body, and don’t know what it does. So the major purpose of chemistry review is i. To ensure that the compound is adequately reproducible ii. To ensure that the compound is adequately stable In addition to this the sponsor should discuss any manufacturing and chemistry differences between the drug product proposed for the cli nical use and drug product used in animal toxicology studies.However these differences might affect the safety profile of the drug product and need to be stated if there are no differences. V. Pharmacology or Toxicology Review: This committee is a group of pharmacologists and toxicologists who evaluate the results of animal testing made during the clinical trial and compare it with the potential effects in humans. That is to ensure safety of the humans for the new drug. i. Pharmacology and Drug Distribution (21 CFR 312. 23(a)(8)(I)): This is nothing but absorption, distribution, metabolism and excretion of the drug in the animals.These results should be obtained by conducting them in animals, so it should be recorded with an example. Moreover this should not be a reason for the clinical hold because these rae the studies conducted in phase one of the IND and where FDA feels it as sponsor great responsibility factor for the drug in achieving safety and efficacy to the humans. ii. Tox icology Data (21 CFR 312. 23(a)(8)(ii)(a)): INVESTIGATIONAL NEW DRUG REVIEW PROCESS Toxicology data is required from both vitro and vivo studies, because particular studies depend upon nature of the drug and phase of human investigation.VI. Safety Review: After submission of the IND to the CDER then the committee takes about good 30 days to conduct review in every factor to achieve safety and efficacy and to avoid potential harm to the human. The review is an ongoing process however CDER notifies the sponsor immediately if there are any potential high risks associated with the drug upon usage in humans. If a notification is sent to sponsor then it is clear that the application is put on hold and the sponsor should conduct enough studies to clear the hold.This hold will be removed and allows the sponsor for further studies only when changes made to the clinical hold achieve the safety and efficacy and does not case potential risks. If the sponsor is not notified with any information from CDER from the day of IND submission to the 30 th day then on the 31st- day further study can be proceeded as submitted. VII. Clinical Hold Decision: The Clinical hold is issued in during the thirty day review period and this is due to the following factors 1. The drug causes potential harm to the humans 2.If drug is not having enough stability 3. The IND does not contain sufficient information required under 312. 23 to assess the risks to subjects of the proposed studies 4. The plan or protocol for the investigation is clearly deficient in design to meet its stated objectives. And CDER can hold the studies during the initial phases of the studies that is when filed for IND if observes potential risks on the data submitted initially. The Clinical hold will be removed if the sponsor addresses the issue based on the hold before the order is removed.In addition the clinical holds are reviewed by higher authorities of CDER to assure scientific quality and consistency in the Center's clinical hold decisions. IX. Notify Sponsor: X. Sponsor Notified of Deficiencies XI. Study Ongoing Xii. Conclusion†¦.. Page 17 and page 18 lo matter unnnadhi †¦ use gooogle search for material if required and provide the refrence where ever u grab the material†¦Ã¢â‚¬ ¦ Refrences: http://www. accessdata. fda. gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch. cfm? fr=312. 42 http://www. fda. gov/downloads/AboutFDA/CentersOffices/CDER/ManualofPoliciesProcedures/ucm082022. pdf

Friday, August 30, 2019

Future stage Essay

Choose the stage that has been the biggest challenge for you, thus far. Explain what you have learned about a â€Å"future stage.† How will this information benefit you as you reach that stage? Choose at least three specific goals you have set for yourself as you continue through your lifespan and how you will achieve those goals. How has this course helped you determine those goals? I would have to say Stage 6 universal ethical principle orientation adopt an internal moral code base on universal values that takes precedence over social rules and laws. I have learned that even if you need something don’t steal it. Stealing is the most worst thing you could ever think of. This has reach me not to steal even though I don’t but I will never steal. My three goals is to have money to get what I want not to steal, earn things, and reach to get what and the things I would like to have in life. Choose the stage that has been the biggest challenge for you, thus far. Explain what you have learned about a â€Å"future stage.† How will this information benefit you as you reach that stage? Choose at least three specific goals you have set for yourself as you continue through your lifespan and how you will achieve those goals. How has this course helped you determine those goals? I would have to say Stage 6 universal ethical principle orientation adopt an internal moral code base on universal values that takes precedence over social rules and laws. I have learned that even if you need something don’t steal it. Stealing is the most worst thing you could ever think of. This has reach me not to steal even though I don’t but I will never steal. My three goals is to have money to get w Choose the stage that has been the biggest challenge for you, thus far. Explain what you have learned about a â€Å"future stage.† How will this information benefit you as you reach that stage? Choose at least three specific goals you have set for yourself as you continue through your lifespan and how you will achieve those goals. How has this course helped you determine those goals? I would have to say Stage 6 universal ethical principle orientation adopt an internal moral code base on universal values that takes precedence over social rules and laws. I have learned that even if you need something don’t steal it. Stealing is the most worst thing you could ever think of. This has reach me not to steal even though I don’t but I will never steal. My three goals is to have money to get what I want not to steal, earn things, and reach to get what and the things I would like to have in life. hat I want  not to steal, earn things, and reach to get what and the things I would like to have in life.

Thursday, August 29, 2019

Euro Currency Essay Example | Topics and Well Written Essays - 2500 words

Euro Currency - Essay Example Free trade is one of the main benefits of euro. With this 'relaunching', the European integration process has become increasingly biased in favor of deregulation and the free play of market forces, establishing the primacy of negative integration (market liberalization) over positive integration. European integration thus has come to be bound up with a restructuring of Europe's socio-economic order (Barnard 2007). The acceleration of European integration on the one hand, and the rise of neo-liberalism in Europe on the other, have become intertwined inasmuch as the relaunching of Europe went hand in hand with the reconstruction of the post-war order of European capitalism along predominantly neo-liberal lines. The free market has always needed the state for both its emergence and its maintenance. In political economy, the market is not a 'spontaneous order' (Barnard and Scott 2002), but rather a social and political construction, hence, in this sense, as is also stressed by the new in stitutionalism in economic sociology, the economy is always embedded in society (Barnard and Scott 2002). Euro is defined as a single European accounting currency and an official currency of the European Union. "The role of the euro as an international investment currency, anchor currency and reserve currency is inseparably associated with its internal stability" ((Barnard and Scott 2002, p. 54). Today, this is an official currency 15 Euro states and Eurozone. Euro was introduced in 1999, but practically launched only in 2002. Critics admit that: "the euro has a good chance of becoming a lastingly stable currency, respected by the markets and the population alike. Domestic stability is at the same time the best contribution the euro can make to a sound, viable and stable global financial system in which the financial market players can act in a spirit of responsibility" (Barnard and Scott 2002, p. 54). The advent of a single European currency, alongside enlargement and the growing international role of the EU, as codified in the SEA, TEU and Amsterdam Treaty, gives rise to questions rega rding the type of actor the EU constitutes for external partners at the start of the twenty-first century. In this respect, debates over the EU's future parallel some of those which preoccupy Japan in the post=Cold War world. Euro makes possible a higher level of competition for the EC as well as increases its economic growth and ability to face international competition. Clearly, the EC's internal market is also affected by the scope of its commercial transactions. Compared to the United States and Japan, where international trade accounts for only 6 and 13 percent of the GNP, foreign trade is much more important to the economies of the EC (Bieler and Morton 2001). Besides, the internal market reinforces the significance of trade between the members, which is already around 55 percent of the Community's foreign trade. This increase of the EC's foreign trade results in a double

Wednesday, August 28, 2019

Holocaust Essay Example | Topics and Well Written Essays - 500 words

Holocaust - Essay Example On the other hand, there were organized rebellions and resistance, bolstered by internal support as well as a reaction to external reasons. One thing that may have hindered Jewish resistance during this time was that there was the problem that Jews who did fight back or escape often faced an ambivalent setting in other nations. After the early twentieth century, and arguably long before this as well, the climate in Europe was changing towards a status quo which was turbulent, to say the least, towards those of the Jewish faith: â€Å"at the end of World War I†¦ groups blamed the Jews for the social disruption, political instability, and economic crises that ensued† (Leventhal 2008) At this time, around 1934, the Nazis also began to persecute Jews. Laws were passed banning Jews from respected professions, and the boycotting of Jewish stores was encouraged. In the same sort of blurred reasoning that made the Nazis see the Reichstag building as an enemy, the Nazis considered Judaism to be an ethnic rather than a religious distinction. Therefore, even citizens who had converted to Christianity were considered to be Jewish if they had Jewish ancestry. This is at the very least ironic, since according to many sources, Hitler himself came from Jewish roots. During this period, the Nazis â€Å"encouraged boycotts of Jewish-owned shops and businesses and began book burnings of writings by Jews and by others not approved by the Reich† (Leventhal, 2008). This was a backdrop against which organized rebellion was very difficult. It was also hard for Jews to fight back against the Nazis because the Nazis were in charge of an enormous propaganda machine that influenced the German people. Propaganda was also important to the expansion of Nazi power. One instance of In Spigelman’s recent story about the Holocaust â€Å"Maus,† the narrator Artie confronts questions of why the Jews did not

Tuesday, August 27, 2019

Taxi of the dark side Movie Review Example | Topics and Well Written Essays - 1000 words

Taxi of the dark side - Movie Review Example The movie in this particular case is Taxi on the Dark Side. This is a movie, which points out some of the inhuman acts, which are carried out against the Afghan nationals. These acts are in most cases perpetrated by the troops who are on missions in the country. The central theme here is the torture of an Afghan vehicle driver who is tortured and beaten to an extent that he ends up dying while he is in detention. The activities that are highlighted in the movie can be explained in some theories for the purpose of pointing out the intricacies that come into play. The one theory, which is highlighted here, is the Magic Bullet Theory. Initially, it was believed that the media was an important tool, which would bring about positive changes in the society. This is one belief, which was particularly upheld before the new millennium. This theory especially had significant influence during the World Wars. There were several movies and depictions made for the purpose of elucidating people on the happenings at that time. The mode through which the information was communicated was done in such a way that people were very receptive of the message. The one thing which is of the essence to note with regards to this theory is that it is majorly reliant on assumptions as opposed to scientific facts. The assumptions in this case are that the mind of the human person is not reliant on the findings that are established from research. In relation to the theory, the media has taken significant advantage of the fact that people may not want to dig deep for the purpose of finding out the truth about a particular phenomenon. Instead, the people will be receptive of whatever is presented to them by the media instruments. However, in the recent times, the notion that the media may be a tool that brings about change in the society is something, which does not hold anymore. This is something, which is once again pointed out by the happenings on the ground in a country like Afghanistan. Th e atrocities which are carried out against the local inhabitants is within the know of the media personnel. For example, the issue of torture, which is depicted in the movie, may end up going without getting addressed. There is very little which has been done especially with regards to making follow-ups of the various cases that emanate. Also, in as much as these issues are brought to the knowledge of the relevant authorities, very little can be seen with regards to addressing the problems at hand. There have been several cases, which have been brought forth, even to the United States Government. However, it seems that the right measures are not put in place especially in alleviating the situation on the ground. The punitive action, which is also prescribed for the perpetrators, does not seem to be highlighted. If they happen to be brought to the public eye, in most cases these punitive actions seem to be things which can easily be left to slip. These happenings clearly point out th at the impact, which the media initially had, has been watered down to an extent that people can be left suffering while nothing is done. The individuals in the armed forces continue carrying out their activities on other helpless people without showing signs of changing behavior. The other theory,

Monday, August 26, 2019

EPI7005_2 Essay Example | Topics and Well Written Essays - 2500 words

EPI7005_2 - Essay Example Such inhomogeneties may be a result in some imperfection within the magnet or magnetic susceptibility spatial variation of the object that is being imaged (Christ, 2000, p. 78). The spatial variation is normally referred to as susceptibility artifacts. EPI applied in most of protocols used in diffusion weighted acquisition uses a homogenous static field. Such a field does not normally hold for MRI head. The distortion that comes out of this is significant enough to even exceed ten millimeters. Such artifacts come in the way of accurate diffusion images alignment with structural MRI and are considered obstacles to the head MRI joint analysis of structure and connectivity. Some of the methods used for correction of magnetic susceptibility distortions include the use of a filed map. However, such methods of applying field maps are not reliable and accurate; hence, they do not result in reliable EPI alignment with structural images that correspond to it. The T2-weighted structural image approach that relies on EPI baseline image and still gives account of the susceptibility artifacts is the recommended approach (Edelman and Schmitt, 1994, p. 610). How accurate the reconstruction of the image is depends on the spin’s resonance frequency (rf) which is formed normally through a spatial linear gradient superposition and an external filed that is homogenous and strong. The above conditions have to meet failure to which the anatomical structures relative positions will end up being misrepresented in the MRI image reconstruction. A good example of this is a case in which a spin is presented to a magnetic field that is not the same as the expected value resulting from the magnetic susceptibility. In this case, the geometric distortions process will be witnessed from the MRI image (Reinsberg, Doran, Charles-Edwards, and Leach, 2005). When the spin is increased, it leads to the production of MRI signals whose intensity is relatively low while areas having high magneti c susceptibility experiencing total signal loss (Zhou and Gullapalli, 2006). Question 1A Several parameters have to be reduced in order to optimize EPI image, and they include: A. Reducing the time of echo train length: the longer the length of the echo train, the more time is required by the spin to gather phase error and the greater the distortion witnessed. One of the ways of minimizing the total time of train length is by minimizing the echo spacing. The less the time is taken by the frequency gradient in sampling the signal, the less the distortion will be witnessed as shown in figure 1. The period for sampling is normally during the flat readout gradient portion unless there is ramp sampling. In FSE, the less the ESP or the echo spacing is, the less the blurring of the image gets. In EPI, minimizing the echo spacing also results in a reduction in the blurring and geometric distortion. Figure 2. The sampling time and the read encoding gradient during normal gradient performance (McMahon, 2012) As the segmentation degree increases, the echo number acquired per rf excitation decreases. This in turn minimizes the geometric distortion as the phase error time of accumulation is reduced. Figure 3 below demonstrates the reduction in

Sunday, August 25, 2019

Charter Research Paper Example | Topics and Well Written Essays - 1250 words

Charter - Research Paper Example APEX brings together all business programs and units for efficiency in running the company as a whole. The Six Sigma Strategy is used by the company to improve its business operations. The improvement project as a whole aims at making sure that these best practices upheld by Raytheon function as they are supposed to for the general well-being of the company. The Program Management College is meant to provide training courses for the company managers and for other employees as well. Raytheon has always faced challenges in phasing out the start-up process of many of its running programs. To improve on this, it has established the Program Start-up process to ensure that every initiated program in the company has more than enough to see to it that it starts on a high note. The Program Management Forum aims at providing opportunities for managers to network and exchange ideas with managers of other companies on the best managerial skills. The management of the company has identified the existence of a gap in its business model whereby they report to the wrong people. This led to the creation of Program Structuring, Learning and Effectiveness to ensure more accountability on everybody’s part. This project is further based on a strong matrix model where reporting is done through integrated business models and cross business teams. These models are aimed at ensuring that the company is effective, efficient, and capable and utilizes its working capacity to the maximum. Raytheon has identified the need to improve its services and products. One of the major reasons for so doing is the rapid increase in the rate of competition for the services and products it offers. The company wants to become the best in the world of defense and information technology, hence the need to roll out a program that will help it to achieve this goal. The company has also established various goals that it wants to

Saturday, August 24, 2019

How the Zomia interacts with Thailand politics Research Paper

How the Zomia interacts with Thailand politics - Research Paper Example The 2006 coup de tat and other physical elements have been attributed to the two camps. The strategic position of Thailand in Zomia has been seen as a key element that has shaped the nature of politics of this nation, as some elements of the past are still prevalent. Thailand is situated in the epicenter of Indochina peninsula in the Southeastern part of Asia. Thailand politics has attracted attention all over the world. It has a monarchy kind of leadership with the current leader being King Bhumibol Adulyalje, Rama IX (McCargo & Hongladarom, 2004). The king has served the country since 1946 and has been termed all over the world as the longest serving personality in his capacity as the head of state. His monarch has served the longest in the history of monarchy in Thailand. The nation is at present ruled by a military junta that seized power in 2014. The politics in Thailand are characterized by a number of elements as influenced by the culture of the one Zomia and those from the lowlands. The recent political crisis in the country since the wake of 2005 has seen the onset of two perspectives; the yellow shirts and the red shirts (CNN, 2008). People’s Alliance for Democracy (PAD) and the Peoples Power Party (PPP) have played a big role i n the recent political crisis. The conflict between the two parties would later translate to a conflict between Democratic Party led by the Prime Minster Abhisit Vejjajiva government and the National United Front for Democracy against Dictatorship (UDD). UDD followers normally dress in Red Shirts while PAD followers dress in Yellow shirts (BBC, 2012). The yellow color is preordained to embody the royal aspect of the reigning king of the nation. The UDD red code is a sign of support to Thaksin Shinawatra, a deposed prime minister. Thailand is a center of two bitter camps, the Red Shirts, and the Yellow Shirts. The birth of the color codes is more dependent on

Friday, August 23, 2019

Critical analysis Essay Example | Topics and Well Written Essays - 500 words - 1

Critical analysis - Essay Example He is put in an asylum. The place- Villete, an asylum in the city of Ljubljana. And the author- an expert storyteller, Paulo Coelho. Though, the plot of the story may sound gloomy but the story keeps the reader engaged as it unwinds. Because, you can relate to atleast one of the characters, you are eager to find out what happens next. You want to know the path taken up by the characters. Perhaps, you could follow the same. And the path that you should follow in life is revealed by Paulo Coelho in the most amazing way. You will find it difficult, if not difficult, impossible to disagree with him. The battle of every character is painted by Paulo Coelho with great detail. On one fine day (11 November 1997), Veronika simply decides to die. She swallows sleeping pills and peacefully waits for her death. She could have used some other method of committing suicide but the book explains why she uses sleeping pills- â€Å"Obviously she could have thrown herself off one of the few tall buildings in Ljubljana, but what about the further suffering caused to her parents by a fall from such a height?† Veronika fails to realize that her death will, anyway, bring misery to her parents. Veronika is saved and admitted to an asylum. In the asylum, she is told by Dr.Igor that her suicide attempt has succeeded but she will live for another five days before she dies. Veronika had planned to die quickly. But waiting for your death is different. And so, begins the five day ordeal for Veronika. Many of us commit suicide and die a cowardly death. This happens in a matter of a few minutes. How quickly the scenario changes when you have to wait for your death! You know that every minute is taking you towards death. And so you want to make the most of it. That is what happens to Veronika. At the asylum, Veronika meets other ‘mad’ people.

All About Malaria Coursework Example | Topics and Well Written Essays - 1000 words

All About Malaria - Coursework Example 451). As studies indicate (Rietveld & Schlagenhauf 2008, p.214), malaria produces more complications in pregnant women and young children because these groups are more vulnerable to malaria. If diagnosis for this infection is not done at proper time, it may lead to disastrous results. The disease is said to have supplied by chimpanzees and gorillas to mankind. The comparative lack of genetic variations in plasmodium falciparum also testifies that it has the recent origin from some other primate species (ibid). How malaria is caused Normally this disease is transmitted to people by a certain kind of female mosquito called Anopheles. These parasites are usually found in the saliva of the female mosquitoes of this type. As described by Jacoby and Youngson (2004 p. 1123), when a person is bitten by a female mosquito, the parasite enters the bloodstream through the mosquito’s saliva and makes their way to the liver. Initially, they cause no troubles, but the infected liver then get s damaged releasing merozoites that badly affect the red blood cells (ibid). The multiplying parasites eventually cause the signs of malaria in the host. As stated above, the parasite that causes malaria is called a plasmodium. Typically, there are four different species that cause this disease in man. They are plasmodium falciparum, plasmodium malariae, plasmodium vivax and plasmodium ovale. Among them, the most dangerous one is plasmodium falciparum as it causes most serious complications and often becomes fatal. The rests are less malignant that cause severe fever at alternative intervals. Another peculiar characteristic of these non falciparum parasites is that they may get into the liver and be inactive for long; and the disease will be caused long after original infection (ibid). The different phases of communication and the life cycle of malaria parasites in the human body are illustrated in figure 1. (Figure 1: Source: Davis & Shiel, n.d.) Symptoms of Malaria If a person is affected with malaria, the signs will be visible from ten to twenty eight days of the mosquito bite. The first sign will be tiredness and loss of liveliness. The affected person will have continuous muscle pain and pain in the joints. Some other symptoms of malaria include fever, headache, nausea and diarrhea. The symptoms also include shivering and fever, heavy sweating and fall in temperature. As Ichhpujani and Bhatia (2002 p. 98) points out, Blackwater fever is another complication of malaria in which red blood cells break and release hemoglobin directly into the blood. Cotter (2001, p.39) finds that hemolysis, which is the phenomenon of red blood cell breakage, is the direct cause of Blackwater fever. The most alarming factor about malaria is that the parasites have developed resistance to a number of malaria medicines. Malaria Diagnosis It is a hard task to diagnose malaria with the clinical criteria as the general symptoms of malaria such as fever and headache are common to a number of illnesses. Therefore, in highly industrialized countries where malaria is rarely reported, physicians have to order special test to identify the presence of malaria. The widely used method of malaria diagnosis test is the Giems blood smear on a microscope slide that is discolored to show the parasites that have got into the red blood cells. The slide of such a blood smear showing Plasmodium parasites are pictorially represented in figure 2. (Figure 2: Source: Jacoby & Younson, 2004.). Though this test is comparatively easy, the

Thursday, August 22, 2019

My experience Essay Example for Free

My experience Essay Over the summer, I took a trip to Mission Beach with my family and friends as we do every summer and Christmas break. Each year we always take a night to go to our favorite restaurant, Tower 21. The refreshing atmosphere, top-notch service, and mouth watering food is what we come back for and they never fail to meet our expectations. This last experience, however, was different than what we were expecting. My family and I were all very ecstatic about getting dressed up and eating delicious food after our long week of burgers and hotdogs by the campfire. When we pulled up to the valet for the restaurant we were greeted with a smile and a quick valet parking process. This was not something out of the ordinary, more of something expected. As we entered the entrance of the restaurant, again, we were greeted with friendly faces that immediately sat us at our reserved table. Our waitress then came to our table and introduced herself very nicely, just as we expected. The beginning of our meal went exceptionally well. Our waitress and bus boy even had a few personal conversations with my family making us feel even more comfortable at the restaurant. But once again, this was something that we always had the pleasure of enjoying when it came to the guest service. After our appetizers were finished, that was when the whole experience changed. Around the corner we could all see our entrees coming our way. The entrees were served with happy faces all around the table. After our waitress made sure everything had come to the table, she went back to her other tables. Each of us began to cut into our steaks in front of us. Immediately you could see disappointment on a few of my family members faces. What they expected to be a perfectly medium rare steak ended up being a medium well steak. At this moment our â€Å"experience† turned to a downward slope. My father called over the waitress to tell her about our complaint. She apologized for the over cooked steaks and had them sent back to the kitchen for new ones. The manager of the restaurant along with our waitress brought over the brand new steaks to make sure they were properly cooked. Of course, this time they were even better than perfect.

Wednesday, August 21, 2019

Market structures in practice at Unilever deviate

Market structures in practice at Unilever deviate Market structure is the manner in which a corporation experience competition during the delivery of goods and services. The structures are very dynamic and both extremes do exist depending on the market in which one is operating and the type of goods being dealt with. The theoretically existing market structures are: perfect competition, monopolistic competition, oligopoly and monopoly. Out of these existing market structures, it is not possible to single out one to be prevailing in the Unilever products market. This so because there is no clear cut differentiating between them. However, perfect competition is a far much distinct structure from the other three structures. Unilever has a wide range of its consumer products in distribution worldwide. The corporations complexities in organizational structure coupled with an expansive portfolio of products have made the Unilever company operate in all market structures except perfect competition. Perfect competition prevails when there are many sellers and buyers present in a market. This means that no single player will bring much influence in the entire market. The presence, withdrawal or change of strategy by a distributor in this market structure has an insignificant effect in price and demand. The market forces are left to take their full swing operation. In this market, the consumers view all products to be identical thus selection of a product to be purchased is indiscriminate. However, this is not case in most household consumer products. Consumers are very sensitive in the selection of such products, especially those that affect their health and general appearance. The earlier mentioned expansive portfolio of Unilever house hold products affects the final consumers health and appearance. This effects either instant or long term are evident in its advertising slogan; adding vitality to life. By considering the corporations profile, Unilever is not the type in which it s presence in the market cannot be felt by fellow competitors as well as consumers. Therefore, saying that a perfect competition is the kind of market structure in which Unilever is operating will be a complete fallacy. Monopolistic competition prevails when there are few restrictions to the entry of the market. The presence of a corporation in the market will therefore be determined by it creativity and ability to overcome the few existing restriction. Such restrictions may not necessarily be economic but rather anything which may retard the growth and performance of a player in that particular market. The many companies operating in this kind of market structure have little to influence since they have small market share. Unilevers market share cannot be generalized as small globally but rather largely variable. It is dependent on geographical diversification characterized by expansion and venturing into emerging markets. The aspect of small market share may not be entirely dismissed but can be stated as a fairly potential scenario to occur. This is evident in the penetration in to the new markets already colonized by competitors as well as situations where others are proving too strong to eat int o the corporations market share. The products in this case are very distinct thus one can easily differentiate between products of different companies. The Unilever products can easily be identified and are available in a large sea of household products from which a consumer chooses from. The marketing strategists in Unilever must therefore apply non-price competition strategies. Advertising is the most common non-price strategy available for Unilever, where fellow market players have close substitutes of its products. Another tool in use by the corporation is the rolling out of an ambitious research and development program which has seen it deliver the most optimal innovative designs of products. All these characteristics describe a monopolistic competition which becomes one of the prevailing market structures. Oligopolistic market structure exists when a few firm dominate market and thus enjoys a majority of market revenue. This is evident in its market share which according to Fortune 500 list of large companies in Europe, it revenue was at $ 45,679 million which placed them at fifty-fourth slot in the year 2000. This commanding market share coupled with European Union stringent standardization rules makes it hard for new products to hit the market. The Monopoly on the other hand means that there is only one supplier. Therefore there is no competition expected. The sole supplier dictates the prices, supply quantities and the quality control. This hypothetical structure hardly prevails unless there are influences from regulators like governments and other authorities empowered by pacts and international agreements. There are high barriers making it totally impossible for other firms to enter the market. It is hard to experience this kind of a market structure currently. It can only be seen in specialized products distributed by the government due to their nature to influence the national security. We can therefore confidently dismiss this structure to be non-existing in Unilevers products. To sum it all, all market structures except monopoly are in practice at Unilever. However the perfect monopolistic structure carries less weight because the cumulative market share of this corporation is big enough to shake off potential high caliber competitor. Any organization interested in the manufacture and distribution of household goods can only do best by either franchising or merging with Unilever. The consolidation of European resources through European Unions elimination of trade barriers and restrictions has come up with far reaching opportunities as well as setbacks for main stream organizations. For Unilever, it is a great milestone as it is for other multinational organizations to see different regions get in to agreements of forming trading blocs. The usually complex management structure can be simplified through creation of regional offices. The basis of such regional offices is going to be the preset blocs. Relationship between market forces and Unilevers response Market forces are the demand and supply which is a reflection of all price-conscious sellers and buyers of the products available in the market. The desires of sellers and buyers are in the two extreme ends. Sellers will want the highest possible prices while buyers want to own the goods for free if possible. Since taking goods freely is not possible they are therefore asking for minimum prices possible. The price is expected to go up with an increase in demand while an excess supply will make the price to fall. Such varied desires constitute never ending market forces. It is worth to note that the market forces are only possible when there are no external interferences. The already mentioned rich portfolio of Unilever products can be put into the following categories: washing powder and detergents, beverages and butter and margarine. These products must attract many buyers as well as producers being the fast moving consumer goods demanded by buyers daily. In fact the demand is poised to rise given the ever rising populations of the world accompanied by rapid urbanization. It is the dream of every organization in business to make profit and reduce cash outflows as much as possible. Unilever being no exception has put in a lot of efforts to stay up beat so as to maintain and grow its market share both in Europe and global market. We are now exploring its response to such dynamic challenges accompanying variations in market forces, the actual effects in revenue and long term reputation of the corporation. The corporation has a deliberate effort to guard its market share. The main strength of Unilever is the expansive geographical diversification of its products. These will translate to the final returns because; the poor results of one region are likely to be cushioned by those of the other. To illustrate this, the corporation was in operation in eighty eight different countries in the year 2002. Management teams in every region were given decision making autonomy so that the products available for distribution in their respective regions are tailor made to just meet the consumer needs. This brilliant approach ensures the avoidance of obsolescence as well as delivery of the most relevant goods in the market. Paying attention to human capital offers enormous opportunity to the long term strategy of the corporation. This global organization believes that a highly motivated human capital is going to impact positively on the general outlook. It is this reason therefore that has made the company to invest on human resources development through recruitment and training of employees from varied disciplines and qualifications. To ensure that every talent in the society is utilized one can enter the companys amazing human resource through graduate trainee program or specialized skill direct entry. Another notable strategy which may look more of welfare based than economic is the formulation and implementation of a well detailed safety, health and environmental policy. This has a lasting perspective and a wide focus beyond what can be immediately seen. However, there are short term benefits of this. An employee who is always safety conscious is going to deliver better results than the other who has no attention to safety. It is also worth noting that some economic blogs like the European Union cannot accept a companys products if there is not practical move to conserve and protect the environment. The most recent example is the black tea sourcing sustainability commitment which came by through the certification by Rain Forest Alliance. Among the immediate benefits of this tea sourcing sustainably, Unilever has been able to launch its Rain Forest Alliance compliant tea in the European market. The years of poor performances globally prompted the organization to embark on an ambitious path to growth strategy in the year 2000. The strategy has specific action points to be discussed next. First of all, the ambiguity surrounding the amorphous number of brands was eliminated through the reduction of brands to the four hundred most important core products. The unsuccessful brands were successfully removed from the market which led to the increase in sales of the top brands from 75% to 93%. The corporation has been able to also tap from emerging markets by penetrating those which are already colonized by the competitors such as; Procter Gamble, Nestle and Kraft Foods. Among the major advantages of Unilever is it ability to carry out research and identify the consumer trends of needs. With this information at hand, the response is efforts to cater for them. Just to illustrate this proactive approach, the major concerns in the world of late are nutrition and weight. Majority of the people are currently shifting their focus to ways of living healthier lifestyles. So as to move in tandem with this trend Unilever acquired Slimfast, an organization offering weight management services and nutritional consultancy. The intense competition faced worldwide has necessitated the Corporations top management to make acquisitions. The top acquisitions are Ben Jerry, Slimfast and Best Foods among other twenty worldwide. This ability to make huge acquisitions and conglomerate firms hav e put itself in a position to enable itself enjoy competitive advantage. The corporation saved EUR750 in cost and operating margins rise by 15.7 per cent in the first three quarters. The Unilever is carefully working together the Competition Commission so as to achieve a balance between their profits and legitimacy. Striking a balance has been a headache for both parties bearing in mind their varied intention of promoting competition. Competition Commission will always strive to provide a fair play ground for the players in a given industry. It ensures also that no one takes unfair advantage by punishing the final consumer. To achieve this, the commission closely monitors the interaction of competitors and partners in the market. The changes in businesses set up including concentrations through mergers and takeovers are very useful so as to eliminate the competition among the players in the market. The resent proposed acquisition of United States based Sara Lees body and laundry division by the Unilever is being reviewed in line with European Union Merger Regulation. The commission seeks to establish the ultimate effects of shelf prices of these products after th e elimination of competing suppliers of a good number of household cleaning products. Through such a strategy, the corporation is able to wade off expenses that could have resulted from competition and huge advertisement. However, if this is viewed as move to club together and drive others out of business it will be totally unacceptable and the commission is going to advice the relevant bodies accordingly. Sanctions and license suspension may the worst penalties that the company can get if found guilty. But leaving alone this pessimistic approach of the role of competition Commission, there are a lot to be achieved. The corporations expansion strategy has seen it adopt an earlier mentioned path-to-growth master plan aimed at growing it market share. Its unrivalled enormous infrastructure has played a paramount role in venturing into emerging markets. The other strategy has been the focus on the internal structures of management and building of global leadership. A well oiled management machine has been achieved through internalization of the concept of growth by every member of the management team. The history of this company shows us that it is a merger of two companies based in United Kingdom and the Netherlands. With this foundation, there has been need to cluster the two head offices resulting in a simpler organizational structure. A fast decision making and improved accountability can only be achieved through the continuous improvement of organizational structure. Importance of foreign international trade, economic integration and global markets in Unilevers business International trade is the exchange of goods and services through the borders. This type of business has formed the firm foundation in the modern business world because the manufacturers and distributors attempt to gain from a wider market rather than looking at their own borders. Each and every firm intending to throw its nets wide must focus on the globalization of its marketing and distribution operations. The foreseeable constraints of venturing into international trade are deeply rooted in the standardizations and trade barriers formed through economic integrations and blocs formations. Many economies have leant that they cannot effectively compete with the do-it-alone approach. Therefore there is a rise in regional economies coming together and forming a bigger economy. This grouping and regrouping of states have a huge impact on the social, political and most important economic dimensions of organizations. There many benefits that come along side this integrations as well as d emerits. Any organization in need of these benefits and willing to take the accompanying risks will surely take these challenges and reap from the goodies of global market. Just like any other multinational firm, Unilevers presence in the global market has helped in the continuous development of new market segment. In order to benefit from the economies of scale, the corporation shakes off the saturation in the European domestic market by gathering for the needs of international buyers. International trade is also important bearing in mind the corporations portfolio resources and products. To tap from these undoubted benefits of international trade, Unilever utilizes the various available options of internationalization. The earlier stated concept of mergers and acquisitions has given the corporation a huge milestone in venturing into international trade. Among the many firms that has entered in a n international partnership with the corporation are: Pepsico which works together to market and distribute Lipton a ready-to-drink tea, Inmarko which is the leading ice cream corporation based in Russia and the imminent acquisition of Sara Lee division of body and laundry production. In a nutshell, the company has been able to secure a total of twenty acquisitions Unilever can therefore be said to be a global corporation based on the attributes described before. This is justified by its presence in many nations and the use coordinated brands in global market. It however has one centralized office in the United Kingdom which manages the entire strategy. The European Union policies which affect tariffs and free trade agreements are going to have a final trickledown effect on the revenues and operations of Unilever. The elimination of trade restrictions and barriers within the European market means that the revenues are going to rise because of easy penetration to domestic regions. The removal of all tariffs on trade is one of the major benefits enjoyed by the corporation. Economic implications emu in the United Kingdom The economic monetary union is the adoption of one currency by the European Union member countries. This move has been achieved through the development of one European Central Bank and formulation of a common monetary policy. Such adoption of single currency has elicited a series of mixed reactions due to the economic implications. Some school of thought may argue that the adoption of EMU is irrelevant because it focuses strictly on the financial services sectors. The critics of Economic Monetary Union claim that putting together economies of different sizes is going to be detrimental. This will mean that the entire Europe economy will be the least common denominator. In simpler terms this will mean that the economic muscle of the member states is going to be achieved through striking a balance between the participating economies. The poorly performing economies are going to pull down the perceived successful ones. Despite this pessimistic view of EMU, there will ultimately be a lot of attractiveness of euro financial assets due to eliminated exchange risk and improved liquidity. In addition the stability in macroeconomic environment is very instrumental in reduction of financing and investments risks. It is no doubt that the introduction of euro as the common currency in the European Union has improved prices transparency. There are no fears by someone using euro resulting from using different currency. The firms in the Unions territory are able to comfortably compare prices without worry of actual value being distorted by conventional highly volatile exchange rates. From an external point of view, the consolidated EMU area is in a position to be self sufficient and independent of the Asian or American influences. Thus partnership has a political effect. The mutual relationships between nations are going to be fostered since the bad blood is eliminated by continually partnering in the formulation and improvement framework of the common market policies. The Eur opean Union firms, in which our organization of discussion is part, are going to increase their profitability through elimination of currency exchange transaction costs. Other trade focused proponents of this worth project claim that no cent will be lost on the fluctuating exchange rates. Trading as a bloc makes Europe compete effectively with other giants in the Far East and America.

Tuesday, August 20, 2019

Project Life Cycle Sustainability Indicators

Project Life Cycle Sustainability Indicators INTRODUCTION A typical meaning of sustainability is hard to build, which represents a test when endeavouring to achieve agreement on the most ideal route in which it might be accomplished, (Mog, 2004). Various stakeholders have begun to adopt the technique of sustainable building, (Zhang, 2014). Developing consideration and interest over the social and environmental impact of business and how the social and environmental (surroundings, habitat, climate) issues affect business has led some companies to strongly report and take care of their sustainability footprint, (Adams and Frost 2008). The building sector has dependably been viewed as an extremely noteworthy front line for advancing sustainable development by more feasible practices in the procurement, planning, design, construction and office administration stages, (Zhang, 2014). Different advances are accessible for implementation in creating sustainable projects over distinctive phases of the projects, including planning, designing and maintenance, (Zhang, 2014), perception of sustainable implementation of projects is essential because of the effect it has on surroundings and environs and also concerns various parties (Bueno et al., 2013; Jeon and Amekudzi, 2005; Litman, 2007). Several indicators have been developed to be able to identify project sustainability at various levels of the project life cycle. SUSTAINABILITY The triple bottom line has been made reference to in several research works, this is often referred to as the 3P’s (people, planet and profit) or sometimes as 3BL, the triple bottom line is referred to as the foundation of sustainability and it emerged in the mid 90’s. Sustainability has been defined in so many ways by so many authors in their research work, but there is still a similarity in the definition, sustainability is about preserving natural resources, the environment for future generations while utilising it, the concurrent development of social, technological, environment and ecology are general requirements for sustainability, (Pons and Aquado, 2012; Terio and Kahkonan, 2011; Abeysundara and Babel, 2010). Kleindoorfer et al., 2005 defines sustainability as the . Since the ideology of sustainable development was introduced in 1987 by Bruntland, a lot of gradual events have taken place to boost the attention on environment and sustainability program, (Zainul A bidin, 2008). Abidin, (2010) mentioned awareness and knowledge as factors that boost sustainable movement, interest, demand and implementation comes after (Du Plessis, 2007). Civil engineering projects has a large percentage of contribution to the environmental sustainability, in construction organisations, sustainable development has been an important issue, (Holton et al., 2010), in an annual report in UK, 42 construction companies were reviewed to have little information on sustainability, (Myers, 2005). Considerable changes related to materials, management, skills, technique and innovations needed in the construction organisation are as a result of sustainable issues, (Glass et al., 2008). The issue of sustainability and how it affects the projects progress has been a rising issue among management teams, in order to address the need towards sustainable development, sustainable evaluation frameworks have been executed by the development industry (Clevenger et al., 2013), several frameworks for assessing infrastructural sustainability of projects has been developed, (Lim, 2009; Clevenger et al., 2013), these sustainable assessment are created either by non-governmental, government or by joint work with academic bodies, some of these assessment schemes are available in state system and also some are available at national level, (Hezri, 2004). Companies that comply with the sustainability regulation are likely to experience loss of income, (Tan, Shen and Yao, 2011), sustainable buildings are expected to have less impact on the environment, although the efficacy of the delivering process would be affected by complications in delivering sustainable building projects, (Horman et al., 2006; Salkin et al., 2012). Several sustainability factors for assessing sustainability have been developed; Lim (2009), suggested some sustainability factors and the impact its implementation has on road infrastructure projects, also sustainable factors for assessing built infrastructural projects were suggested by Ugwu and Haupt, (2007) in their research work; these built infrastructure categorised under project management, economy, resource utilisation and the environment. Several means of monitoring sustainability in projects have been developed, sustainability indicators have been developed by various authors to monitor sustainability at various levels in a project, Dasgupta and Tam in 2005 developed a sustainability indicator (Technical sustainibilty index) based on existing research, also (Ugwu et al., 2006) in their research work proposed a sustainability indicator called the Sustainability appraisal in infrastructural projects. CIVIL ENGINEERING PROJECTS Various civil engineering projects impacts on the environment, Zhang, Wu and Shen, 2014 reported that construction projects expend a large amount of energy, resources, land and water, this leads to consumption of resources and energy. To achieve a sustainable development in construction projects, it is necessary to have a sustainable performance across the project’s life cycle, (Shen et al., 2007), due to the evolving interest in the preservation of nature, construction projects are faced with the challenge of producing a sustainable project, for a construction project to be termed sustainable it must consist of social, economical and environmental factors (Abidin, 2008). In implementing sustainable projects, previous research work has indicated that although it can be time consuming, the cost of its implementation is not as expensive as it seems. Cost, time and quality has been generally described as an essential factor in measuring the performance of construction projects, ( Chen and Chen, 2004), for construction projects to be completed on time is a requirement, although previous research prove that construction projects are hardly completed on time, (Hussin, Rahman and Memon, 2013), Amu and Adesanya, 2011 reported that with a total of 3,407 projects in Nigeria, 1812 were abandoned, 1517 were delayed while only 24 projects were completed on time, also in Vietnam, it was recognised by their government that the completion of projects on time especially government funded projects was a hassle, (Le-Hoai, Lee, and Lee, 2008). Towhid and Amiruddin, (2012) identified that the cause of the delay in project delivering is inadequate planning, delay in design approval, disagreement with design report. FEASIBILITY Notwithstanding, advancing the sustainability in any business area has gotten to be progressively vital and at the operational level inside organizations. In accordance with this advancement, there is a developing worry that social and financial issues have been exceeding natural issues in the current practice of directing project feasibility study, (Jorgensen, 2008). Shen et al., (2010) described feasibility study as a priority before commencing project design and construction, also mentioned in their research work is that the progress of a project is directly affected by the efficiency of the feasibility study. PLANNING Planning is very essential in projects, for a project to be executed successfully it has to be planned properly, (Nowak and Nowak, 2013), linked the success of project to the righ plan at the beginning of the project, also Litman and Burwell, 2006 reported in their work that the need for organised planning in different sectors is brought about by the emphasis on sustainability with respect to human activities. Every project is different and because of this it is difficult to estimate the duration of the planning process, (Schute, 2005). There are various factors that affect the planning of projects, some of these factors are financial, environmental and internal issues that have to do with the project teams such as misinterpretation and lack of understanding, lack of cooperation among team members, in Sozuer and Spang (2014) research work, planning process (duration and cost) is not only affected by financial issues but also government law on sustainable environment (protecting the h abitat), so many other factors were indicated also to affect the planning process DESIGN Due to lack of integrated structured procedure for sustainable assessment, designers use their previous background in designing projects to make judgements on new project design, (Ugwu et al., 2006). Sustainability issues due to different factors that arise during various projects can be addressed at the design stage. Negative and positive aspects in design are identified at an early stage through the use of sustainable appraisal, this early detection makes it easy for problems to be addressed and also to further modify and improve the project design, (Kumar, Rouquette and Lerner, 2012), Mulder (2006) described sustainability with regards to design in his research work as an attribute a design ought to meet rather than a extra precedent. Issues surrounding sustainability should in this manner be considered by engineers amid all design phases of a project through generally incorporated supplements to the ordinary methodology IMPLEMENTATION/BUILDING Few researches recommended that while implementing construction projects, sustainable principles should be embraced, as this can contribute to profit making, (Turk, 2009), however cost appears to be an issue when implementing sustainable civil projects, Zhang, Wu and Shen, 2014 identified cost as the most important factor which affects project teams when they make decision, cost was also identified in their research work to be increased during sustainable (green) construction implementation, Ofori and Kien, 2004 reported in their research also that in implementing sustainable constructions, cost was seen as a limitation. Numerous designers are not eager to push the limit particularly when it implies they need to move the ordinary method for development and wander into another domain of engineering which may bring about more forthright expenses, (Abidin, 2008). The term ‘green’ has been used generally to describe sustainability and protection of the environment either by using recycling materials and / or environmental materials in our daily activities. Green has been introduced in the construction industry as a means to reduce the harm imposed on the environment, in the implementation of this ‘green’ construction, four areas of concentration were listed; the proper utilisation of energy and natural resources, the use of environmental friendly equipments, recycling and environmental awareness, (Zhang, Wu and Shen, 2014), Shi et al., 2013 describes green construction as the use of technology and scientific management to ensure safety and proper utilization of natural resources in engineering construction and also to reduce the adverse effect the construction process would have on the environment. In implementing green construction, three factors were identified to limit the effectiveness of these; cost increase, added time and a finite amount of green resources, Shi et al., 2013.

Monday, August 19, 2019

Themes in Lord of the Flies Essay -- essays research papers

William Goldning’s Lord of the Flies is an allegorical novel where literary techniques are utilized to convey the main ideas and themes of the novel. Two important central themes of the novel includes loss of civilization and innocense which tie into the concept of innate human evil. Loss of civilization is simply the transition from civilization to savagery; order to chaos. The concept of loss of innocense is a key concept to innate human evil because childhood innocense is disrupted as the group hunted animals and even their own. Through the use of literary techniques these ideas are seen in the passage where Simon confronts the â€Å"Lord of the Flies.† The central concern of Lord of the Flies deals with the fall of civilization to the awakening of savagery. The conflict seen in this theme is explored through the dissolution of the young boys’ well mannered behavior as they accustomed themselves to a wild, barbaric life in the jungle. The concept of innate human evil takes an important role in this theme because as the boys grew more savage the beast that they feared grew within themselves. This innate human evil is the beast that destroys civilization as savagery claimed its position. In the passage the â€Å"Lord of the flies† indicates the presence of the beast within the boys. ‘Fancy thinking the Beast was something you could hunt and kill!’ said the head/You knew, didn’t you? I’m part of you? Close, close, close! I’m the reason why it’s no go? (Pg. 143). To make this point cl...

Sunday, August 18, 2019

Scarface - The Greatest Movie of All Time Essay -- essays research pap

The Greatest Movie Ever Made   Ã‚  Ã‚  Ã‚  Ã‚  Perhaps the best movie to ever bless the eyes of any American is the 1983 Brian DePalma gangster movie classic, Scarface. Scarface is the tale of Tony Montana and his journey through his new life in America in the early 80’s Cuban immigrant movement. The movie depicts the American dream, to be successful, perfectly. Scarface and its main star, Al Pacino, also shows movie watchers in detail, the process of going from â€Å"rags-to-riches† since that is what he did in the feature. Lastly, Scarface is perhaps the best movie to ever be made because it basically contains all the characteristics that are that of a great movie.   Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  First of all, Scarface is one of the greatest feature films ever because it illustrates the American dream perfectly, which is to be successful. This story goes in to detail on what some people are willing to do in chase of the American dream. Tony Montana or Scarface was a man who knew what he wanted, but did not have the patience to get it honorably. This description fits many of today's Americans. The fact that so many people can relate to this obsession with obtaining the American dream, is the reason this movie is considered a classic. Though the way he achieved this dream was not honorable and honest, Montana, through illegal means, became very successful at what he did. This movie, perhaps better than Wallstreet (1987), New Jack City (19...

Cheerleading is Not a Sport Essay -- Argumentative Persuasive Essays

Cheerleading is Not a Sport According to Joe Hatton, the author of the article, â€Å"Sports Beat - The sport of cheerleading: It’s more than just pompoms and smiles,† cheerleading is a sport because it requires strength, balance, and coordination. The major claim of the article is â€Å"cheerleading is a sport - plain and simple - and cheerleaders are true athletes† (Hatton C-04). The article offers the following arguments in support of the claim. Hatton claims because cheerleaders are athletes, cheerleading is a sport. Hatton also says cheerleading is a sport because of the competitive aspects. We believe cheerleading is not a sport, because not all cheerleaders compete. Most cheerleaders rarely, if ever, show athleticism. Cheerleading is an activity based on confidence and school spirit. Activities in schools such as debate clubs revolve around the trust, confidence and competition of the team members yet most people do not consider debate club a sport. In Hatton’s article, he acknowledges many people and organization do not identify cheerleading as a sport. The premier collegiate sports organization in the country, the National Collegiate Athletic Association (â€Å"NCAA†), does not recognize cheerleading as a sport (â€Å"Equal Opportunity†). Also, according to the National Federation of High School Athletic Associations, fewer than half the states in country recognize cheerleading as a sport (â€Å"NFHS†). The fact that a respected national athletic organization and a majority of states do not recognize cheerleading as a sport implies that it is viewed primarily as entertainment. We believe the arguments in the article to be unfounded and therefore view the claim that cheerleading is a sport to be untrue. There is more supp... ...leading should not be considered a sport because it is not typically undertaken in a competitive environment and its primary purpose is to lead â€Å"cheering of spectators as at a sports contest† (Dictionary.com). Works Cited Dictionary.com. Lexico Publishing Group, LLC. 2003. 9 October 2003. http://dictionary.reference.com/. â€Å"Equal Opportunity In Intercollegiate Athletics: Requirements Under Title IX of the Education Amendments of 1972.† U.S. Department of Education. 27 August 1997. 9 October 2003. http://classweb.gmu.edu/jkozlows/460tixa.html. Hatton, Joe. â€Å"Sports Beat - The Sport of Cheerleading: It’s a lot More than Just Pompoms and Smiles.† Providence Journal Bulletin 9 May 2003: C-04 LexisNexis CD-ROM. 13 May 2003. â€Å"NFHS.† National Federation of State High School Associations. 2003. 9 October 2003. http://www.nfhs.org/.

Saturday, August 17, 2019

Advantages And Disadvantages Of An Armed Public

It is believed that the safest nations have very strict gun control laws. This strong gun control laws enhances a lower crime rate but that is not always the case. Virginia’s homicide rate is low among other states like the state of Maryland, where unless one is a police or federal officer it is illegal to carry a handgun. (Joyner, 2004).Many will argue that carrying firearms does not make America more dangerous but instead much safer. With a positive thought, if everyone were armed, crime would drop to an all time low. It's just a matter of weather you are educated in this matter or just shooting from the hip. (Kopel, 1995).The result of this is that a law-abiding citizen can get licenses to carry concealed firearms. With the gun crazies and their paranoia such as crazy shooting similar to the massacre at Virginia Tech, and the violence nannies and their hysteria such as drug related shootings, the issue of legalizing or not remains an ever more complicated mess.This paper ad dresses this issue by relating the advantages and disadvantages of an armed public.Pros Of An Armed Public Most legislatures have failed to reach a compromise on some significant issues like concealed carry gun laws and the issue continue bewildering. According to Al Marzouqi on The Badger Herald (2007), he believes that the ban on concealed carry does not automatically translate to relatively low crime rate, which is an important aspect of the discussion.The absence of crime is not a proof that a policy is working. Laws to restrain criminals’ form acquiring weapons do not stop them especially when they are bound on breaking the law. All a ban on concealed carry does is to create a false sense of security that is all too often shattered by a tragedy and prevents law abiding citizens from defending themselves in such situations.Secondly In a small town, backup is sometimes an absent luxury; good citizens with personal firearms can save the situation. Thirdly many lives might b e saved, just by the presence of a gun without necessarily meaning presence of the police.The law does not state that police should always be of aid if called or requested for any help. Police are not required to help and they cannot be sued if they DON'T help.California's Government Code, Sections 821, 845, and 846 states, in part: â€Å"Neither a public entity or a public employee [may be sued] for failure to provide adequate police protection or service, failure to prevent the commission of crimes and failure to apprehend criminals.†Lastly the number of unregistered guns is actually unknown, but it is probably in the multi-millions like the registered ones.These guns would be most difficult to locate, though readily available to the criminals. Handguns are made everywhere too because they are legal in some states and therefore a booming business, so to be successful in eliminating guns in the US, one must shut down the entire world's ammunition industries and their sales c hannels, which is basically impossible.Therefore the issue of not legalizing does not decrease the number of illegal arms, the criminals would still be armed and lack of the legal guns in a system lives the ordinary citizen disarmed.It is logical that a bully with a gun would not attack someone they knew were armed. Guns reduce the number of attempted crimes because criminals are uncertain which potential victims can defend themselves. States with the largest increases in gun ownership also have the largest drops in violent crimes according to Lott on More guns, less crime in 2000.Criminals are deterred by higher penalties. Just as higher arrest and conviction rates deter crime, so does the risk that someone committing a crime will confront on someone able to defend him or herself.The horrific shooting in Arkansas occurred in one of the few places where having guns was already illegal. These laws risk creating situations in which the good guys cannot defend themselves from the bad o nes. (Lott, 2000)Cons Of An Armed Public A gun owner is more likely to accidentally shoot an innocent person than shoot the burglar because they are highly annoyed at the time of the conflict. Secondly allowing people to carry concealed weapons brings about the likelihood of them falling into the wrong hands. Laws concealed carry state that a person applying for a permit must satisfy an existing criterion.The proposed criteria include age restrictions, background checks, legal citizenship, gun safety classes and mental stability. It is believed that with such procedures, the risks of guns falling into the wrong hands would diminish but this is simply not the case. There are several fundamental flaws with these limitations, including the fault on the licensing body.Thirdly laws to legalize owning of firearms would mean that if individuals meet all criteria for the permit, then the state cannot under any circumstances, withhold it from them unless there exist other laws giving a super vising body the right to withhold a permit from a qualified person.Lastly, release of arms to the public means that they will be highly accessible to unauthorized persons such as children in a family setting who can be able to access majority of the family recourses in exception of the firearms. According to HRW in 2006, between 1985 and 1994, murders committed by children with guns more than tripled in America.Crime rates in England and Australia England has strict gun control but their firearms related crime statistic has been steadily increasing. Originally homicides did not increase with the invention of firearms, but instead seems to have fallen sharply as guns became more efficient and widely owned in England. (Kates, 2002).There are enough historical facts that refute claims that guns cause homicide. Violent crime did not increase with increased gun ownership nor did it decline with decreased gun ownership. Firearms closely correlate with car ownership than firearms ownership in England and Swaziland. Like demographics, Geographic’s of gun ownership relate inversely to crime.Conclusion Concealed carry permits should be issued to those who qualify and be revoked when misused. This would also mean that people are not guaranteed permits and if permitted the state should have a right to withhold on matters of security concerns. Responsibilities do go with rights, and many people often conveniently forget that little tradeoff.Gun violence still remains unsolved because it’s unpredictable and uncontrollable.In line with Kate on the issue of if guns cause crime, the best currently available evidence indicates that general gun availability has no measurable net positive effect on crime rates. Guns availability has many effects on violence increases or decreases with the effects largely canceling each other.References: Al Marzouqi, A. (2007, October 30). The Badger Herald. Retrieved 20th July 2008 from: http://badgerherald.com/oped/2007/10/30/happi ness_is_a_warm_.phpHuman Rights Watch (HRW). (2006). Juvenile Crime Rates: Retrieved 20th July 2008 from: http://hrw.org/reports/2005/us0205/4.htmJoyner, J. (2004, July 15). Virginia Gun Laws: Outside the Beltway (OTB). Retrieved 20th July 2008 from: http://www.outsidethebeltway.com/archives/2004/07/virginia_gun_laws/Kates, D. (2002, July 22). Do Guns Cause Crime: History News Network. Retrieved 20th July 2008 from: http://hnn.us/articles/871.htmlKopel, D. (1995). International Perspective on Gun Control: New York Law School Journal. Retrieved 20th July 2008 from: http://www.davekopel.com/2a/LawRev/lrnylstk.htmLott, J. (2000). More Guns, Less Crime: Understanding Crime and Gun control: university of Chicago.

Friday, August 16, 2019

Substantial Problems on Industrialization

At the turn of the century, a spirit of reform known as progressivism took hold of many American people. Less a united movement than a loose gathering of casual and improbable alliances, progressivism targeted the massive problems of an urban, industrialized nation. In spite of resistance, progressives were able to redefine government†s role in American life, make a serious run for the White House, and ratify such lasting reforms. In the nightfall of the 1800†³s, many citizens could see that existing efforts to solve the substantial problems of industrialization were failing. The 1880†³s and 1890†³s were filled with lively debates about how to reform society. The ideas of journalists Henry George and Edward Bellamy were among the most popular. In 1879 Henry George had written a book Progress and Poverty in an effort to explain why an advanced civilization seemed to increase rather than eliminate poverty. George proposed to solve this problem by ending taxes on improvements on land, such as housing and cultivation. George proposed just a single tax – on the value of land itself. Such a tax would make a speculation in land less attractive by increasing the cost of holding land without using it. In 1888 newspaper editor Edward Bellamy published a novel called Looking Backward. Incorporated into the novel was the story of a man being hypnotized and waking up in the year 2000. All of the harsh working conditions, social class set backs, and political corruption that existed in 1887 no longer existed. The reason for such a change was that government had nationalized the great trusts and organized industrial management. Socialists, unionists, and city government reformers also had many followers. Progressives realized that the nation†s free enterprise system often could be unfair, but they did not want to lose the high standard of living and personal liberty it had given them, and they deeply feared the violence of revolution. Thus, progressives were faced with the question of how to preserve what was good about the United States while reforming the bad. In order to protect vulnerable citizens, progressives accepted an increased level of government control over areas once considered private, such as housing and healthcare. Florence Kelley became a leader in the search for answers. She soon became a resident in Jane Addams† Hull House in Chicago. Largely through her efforts, in 1893 Illinois passed a law prohibiting child labor, limiting working hours for women, and regulating sweatshop conditions. In 1954 Supreme Court justice Felix Frankfurter said that Florence Kelley â€Å"had probably the largest share in shaping the social history of the United States during the first thirty years of this century. † Driven by the mounting tide of public demand, an inundation of progressive reform programs flowed through local, state, and federal legislatures. Targets for the proposed reforms included politics, society, and the economy. Some reform mayors led movements for city – supported welfare services. Hazen Pingree provided public baths, parks, and, to combat the 1893 depression, a work relief program. â€Å"Golden Rule† Jones opened playgrounds and free kindergartens and built lodging houses for the homeless. â€Å"Nobody has the right to rule anybody else,† he once said. He thought all people would be good if social conditions were good. Progressive governors and state legislators also were active. Governors Robert LaFollette in Wisconsin and Hiram Johnson in California introduced reforms to make government more efficient and responsive to voters. Progressivism appeared at the federal level in labor and industrial relations, in the regulation of business and commerce. By the time Theodore Roosevelt completed his second term in 1909, the government had filed forty – two antitrust actions. The beef trust, Standard Oil, and the American Tobacco Company were either broken up or forced to reorganize. Roosevelt was not antibusiness. He did not wish to destroy trusts he deemed â€Å"good,† or not harmful to the public, he just felt they should be supervised and controlled. The progressive era also gave way to they sixteenth and seventeenth amendments. The sixteenth amendment allowed government to raise more revenue from wealthy people†s income and less from tariffs that hurt the working poor. The seventeenth amendment took the election of senators out of the hands of legislature; voters were thus allowed to play a more direct role in government. By the mid – 1910†³s, progressives could take pride in the many changes they had helped bring about, such as redefining the role of government in business and politics. Some reformers included Henry George, Edward Bellamy, Florence Kelley, and the nation separated as local, state, and federal. The beginning of the war in Europe brought about the end of the progressive era in 1914, by the end of 1916 the reform period of the United States had sputtered out.

Thursday, August 15, 2019

Unit Assignment

Then, the paper will go into further detail about problems and, dilemmas, that accompanied the old traditional classification. As a consequence of this state of affairs, the psychological community all agreed upon one matter. In short, it's a fact of necessity, that the old terms, â€Å"projective† and â€Å"objective must be parted with. † Finally, substitute terms are needed to be designated as suitable the new placements, and, the community is all in agreement to simply refer to assessment tasks by their specific name. Unit 8 Assignment Historical use of the Terms Objective and ProjectiveMore than 10 years ago, psychologists have been labeling personality tests by dividing them into two separate types either the objective method or the projective method. Many people have seen them in documents, in the same exact way. Those two words continue to be seen in textbooks, in all types of articles, in graduate programs, and, generally all over the place. Historically, many psychologists have become used to utilizing these terms without fully realizing that they do not begin to define, the psychological personality assessment tests that, they are purported to identify. The terms â€Å"objective† ND â€Å"projective† are not only scientifically inaccurate, but problematic from a professional standpoint as well† (Bernstein, 2007, p. 202). Because, science is trying to keep up with today's times they are trying to eliminate those two terms, objective and projective from the lexicon. â€Å"In the interests Of advancing the science of personality assessment, we believe it is time to end this historical practice and retire these terms from our formal lexicon and general discourse describing the methods of personality assessment† (Meyer & Kurt, 2006, p. 223). The old descriptions do not accurately describe a human rationality.Historically, the methods that were used for describing personality assessment tests have always been divide d into two separate parts. The one section has been objective and the other section has always been projective. These words are ambiguous because they have several possible meanings and they are difficult to comprehend, distinguish or classify a certain type personality in these tests. It's like painting a picture with two different colors and trying to classify it, with only two colors. The results of this show that the terms are so unclear, and they have multiple meanings.Unfortunately, the terms objective and projective carry multiple, often unclear, meanings, including some connotations that are very misleading when applied to personality assessment instruments and methods† (Meyer & Kurt, 2006, p. 223). It is essential not to utilize these words as umbrella words because they do not cover everything they are purported to. â€Å"The old and familiar terminology of objective and projective personality tests has misleading connotations that will not Serve the field well as W e seek to have a more differentiated understanding of assessment methods† (Meyer & Kurt, 006, p. 24). Some other reasonable alternatives need to be agreed upon and utilized. These unsuitable words cannot be continued because they are misleading in terminology. â€Å"The unsuitable and primitive nature of the term projective is revealed when trying to arrive. It in umbrella label to characterize tasks as diverse as drawing one's family, telling stories in response to pictures, and stating what an ink blot looks like† (Meyer & Kurt, 2006, p. 224).Problems with Traditional Classification There cannot continue to be a broad-based paintbrush that is applied and entities to label all psychometric personality assessment tests. â€Å"Tests that are not so categorized will tend to be viewed less positively, regardless of psychometric data, because they are, after all, not objective† (Meyer & Kurt, 2006, p. 223). Because of the past, there is too much negativity surroundin g the term, projective. The terminology both, â€Å"objective† and â€Å"projective† are not necessarily what they seem. The term â€Å"objective† is a smokescreen for measures that can be just as subjective as anything else and the term â€Å"projective† is derived from untenable theoretical concepts that have anointed to create confusion in the field for a long time† (Chilliness, 2007, p. 197). Some other substantial problem is when the effects of a test cannot be duplicated by the same test more than one time. â€Å"If assessment psychologists did not derive overarching frameworks and terminologies for classifying psychological tests, those who use, study, or critique these tests would do it anyway.In this respect, it is better that an organizing framework be made explicit (and the logic underlying the framework spelled out in detail) than that multiple contrasting framework and labels emerge in isolation mongo different segments of the psycholo gical community† (Bernstein, 2007, p. 205). The volume of the dilemmas above have all been a culmination of psychologists and psychiatrists in this community and their opinions about the problems with traditional classification.

Wednesday, August 14, 2019

How Iceland Was Formed Essay

Iceland, situated on top of a hotspot experiences severe volcanic activity one of the most well known eruptions was in 2010 when Eyjafjallajokull erupted seriously disrupting European air traffic. Iceland is situated is situated in the mid Atlantic ridge a seam in the Earth’s surface under the North Atlantic Ocean where the Eurasian and North American plates slide apart. This island has more than 200 volcanoes which is thought to be what created this island. This picture shows that Iceland sits on a constructive plate boundary as the newest parts of the island are right in the middle of the island, in fact, the new parts are in such a way that you could probably make out whereabouts the boundary is in relation to island. This theory is also confirmed by the way that the oldest parts of the island are right on the outside of Iceland. This picture shows where island is in relation to the mid Atlantic ridge and as you can see it is almost right in the middle of it. This picture also shows that the plates are moving away from each other, suggesting that the mid ocean ridge is going to get bigger as time goes on. Which means Iceland could expand a bit as well. This picture shows an aerial picture of a fissure zone in Thingvellir, Iceland, that is a land exposure in the mid Atlantic ridge. To the right of the fissure is the North American plate pulling west away from the Eurasian plate which is to the left of the fissure.

Tuesday, August 13, 2019

Literature Review of My Dissertation Essay Example | Topics and Well Written Essays - 1500 words

Literature Review of My Dissertation - Essay Example Prior to the international disaster setting in, it was flourishing and was considered to be Turkey’s trademark and a proof of the active role it played in world economic trade scenario. â€Å"The Turkish shipbuilding industry has made a considerable contribution to the Turkish economy with 1.5 billion $ from new ship building, 1 billion $ from repair and maintenance activities. Furthermore, industry creates an employment opportunity to 25,000 people directly and 100,000 people in total with related industries. In 2007, 98 ships with a total of 670.000 DWT were delivered. 80 Ships and yachts were already contracted for 2008. Over the past three years, Turkey has gone from being the world’s 23rd largest shipbuilder to being 8th on the list.† (Tulay Uyanik) It was truly global in its reach and remained commercially lucrative and profitable for a very long period of time till the worldwide financial recession gripped this business too in its vicious claws. Mr.Zaman, Minister of Transport Binali Yildirim says, â€Å"The shipbuilding capacity has increased by an average of 65 percent in the last four years. The number of shipyards operating or about to start operating in Tuzla as well as in the Black Sea, Izmit Gulf, Yalova, in the Aegean or Mediterranean has reached 60. We used to build ships of up to 20,000 tons maximum but we are currently able to build ships of up to 60,000-70,000 tons.† (www.turks.us) The once-prosperous community of owners who were doing extremely well earlier are now facing a grim situation coupled with many challenges like the over-valued lira which is the currency of Turkey, an unexpected spurt in the overall costs of running the ships and large amounts of contributions made towards the social security benefits of the crew members aboard these active ships. The high costs of protecting the workers’ interests increased the maintenance

Monday, August 12, 2019

Education study Essay Example | Topics and Well Written Essays - 1250 words

Education study - Essay Example Politicians have long been involved in this practice. A good example would be Mitt Romney, a man widely criticized for supporting a policy that calls for English only while simultaneously running commercials in Spanish dialect. This paper will provide insights on the controversies that surround political influence in languages. It explains why these controversies are still relevant. Afar from symbolism, promotion of any language in favor of others can be termed as fundamentally political. This American example forms a strong point of reference to such political language controversies. It would be to some extent right to say that the U.S is probably the home to countless bilingual speaking persons than any other nation on the globe. Culture diversity and linguistics has been extensive for more than two centuries owed to the fact that immigrants settled here from all walks and carried along their language, values and culture. However, regardless of the multiplicity of languages here, there are no limitations to the importance accorded to the common language. There has been a dominant, the colonizers’, language that has advanced to a variety referred to as a Standard American English’s emergence that incorporates native words and conjures its unique spelling and accent (Crawford 145). Those we call the founding fathers made it deliberate to leave designation in the United States of English as an official language mostly probably because it might not have occurred to them given that decision making was actively avoided in an attempt to accord respect to the national diversities. However, this idea has always been considered hostile to interdependence and interests of respective states brooding a tolerant attitude to be favorable. It was not until the 1980s that the anti-minority politics demanded its protection whilst restricting other languages. Political arenas had not taken up the language issues from the

Approaches against Fraudulent Activities Case Study

Approaches against Fraudulent Activities - Case Study Example Hence, even poorly performing firms obtained huge amounts of credits from MCI and this condition adversely affected MCI’s operational efficiency. When receivable collection periods went beyond the stipulated timeframe, the organization was forced to write off some of its receivables. Undoubtedly, this condition caused the firm to experience a rise in its expenses and thereby a decline in earnings per share. Ultimately, MCI’s stock price dropped due to the decline in EPS. As Lyon and Tocco (n. d.) point out, Pavlo used a variety of accounting tricks to convince the management that the level of bad debts and amount receivables had fallen under the safety range. In other words, Pavlo totally manipulated the accounting system to conceal the actual state of affairs of the company. It is obvious that the absence of a well-executed internal check system assisted Pavlo to apply unfair accounting tricks to deceive the company management. A person is not allowed to carry through a transaction from beginning to end under the internal check system. ... situation aided him to employ accounting malpractices such as ‘unapplied cash’ and ‘placeholder credits’ to conceal MCI’s actual financial status. Approaches against Fraudulent Activities If an individual suspects fraudulent activity within the organization where he works, it is advisable for him not to make any false allegation. In addition, he must never try to take any unfair advantage of that fraudulent activity. Every organization has a distinct corporate culture and hence a specific mechanism to report fraud. It is recommendable for the individual to strictly adhere to the accepted fraud reporting mechanism of the organization. If an individual suspects fraud in his organization, firstly he must make an immediate note of his concern. He should specifically try to note relevant details concerning the fraud including telephone conversations, date and time, or names of parties involved. Secondly, the individual has to report the fraud to someone wi th proper authority and experience. Generally, it is better to report fraud to line managers, internal auditors, or whistleblowers. In addition, fraud may be reported to the Monitoring Officer, Chief Executive, or the Director of Finance. The individual should not make any delay in reporting the suspected fraud to proper authorities because such a situation would cause the organization to suffer further financial loss. Finally, the individual should ensure that the authority has taken proper actions over his fraud report; otherwise, he must report the case to higher authorities. Under no circumstance, the individual can disclose his suspicion to public or any other unauthorized person.  

Sunday, August 11, 2019

Paintings by vincent van gogh Essay Example | Topics and Well Written Essays - 1000 words

Paintings by vincent van gogh - Essay Example The essay "Paintings by vincent van gogh" explores Vincent van Gogh's paintings. . He remained in Belgium to study art, determined to give happiness by creating beauty. In 1886, he joined his brother Theo in Paris, who was a manager in Goupil's gallery. There he had a chance to meet with Camille Pissarro, Claude Monet and Paul Gauguin, a French post-impressionist who brightened his very dark skid and to make him such a great Impressionist. In the year 1888, he decided to leave France to Arles where he hoped that his companions would join him and start a school of art (Meier-Graete, 2001). Nearly the end of the same year Gauguin joined him but an incident led Gauguin to leave Arles. Van Gogh pleaded to Gaugian not to leave him by threatening to kill Gaugian with a razor blade. This led him to be sent in an asylum in St. Remy for treatment. He was dismissed from the hospital in May 1890 and kept under close check of Dr. Gachet. Two months later he shot himself to death. He sold only on e of his paintings in his short but prolific career. One of Vincent van Gogh painting is called ‘the potato eaters' was painted in 1885. It is currently in Van Gogh museum in Amsterdam Having hardly been used to the art of painting. Van Gogh portrayed five people and tried to make them as natural as possible regardless the effect of the lamb light cast by an oil lamb which makes the work more difficulty. He was not ambitious for color, since he put the gloomy interior as bright as he could (Sunwall, 2004). Their heads and hands are ugly earthed and relatively bigger than their body, just as they have been made from the land they dig. They seem to enjoy their meal more than a rich man can  do from his exquisite meal. Van Gogh wanted to convey the idea that the peasant people eat potatoes using an oil lamb with the same hands with which they take potatoes from the plate to serve their land. It was his first attempt to create a work that would establish his reputation. It bring s us into common peasants’ expressions on their home settings. There is a young woman looking presumably her husband  an attracting manner (Sunwall, 2004). The artist shows us there is love in them, and the people are sexually alive.  Ã‚  Ã‚      Above everything, the yellow and reddish flame of the oil lamp depicted the existence of warmth and light, mineral-grey space that represents night, terror and the cold world. The painting depicts these people lives as harsh and miserable. For instance, the man sited on the left is lost deep in his thought while the woman pours coffee. They might be thinking of injustice around them (Sunwall, 2004). Wheat field under threatening skies Another is called ‘wheat field under threatening skies’ painted in 1890 remains one of the most debated work of van Gogh’s painting due to its many interpretation by different people. Some people see it as his ‘suicide note’ placed on canvas, while others go beyond the shallow overview of the subject matter and think of a more positive approach (Klein, 2006). The painting conveys a sense of loneliness in the wheat fields depicting his final year kind of life. The separate paths in wheat field and crow with the path represent the present and the future of Van Gogh’s life. The paths are displayed in three sets one in the middle towards the horizon and the other two in each foreground corner. The